Anti-EGF R Mouse Monoclonal Antibody [clone: GFR450]

Supplier: ProSci
33-119
76195-500EA 723.64 USD
76195-500
Anti-EGF R Mouse Monoclonal Antibody [clone: GFR450]
Antibodies
<p>This antibody recognizes a protein of 170kDa, identified as EGFR. <a href=../search_result.php?search_txt=egfr>EGFR</a> is type I receptor tyrosine kinase with sequence homology to <a href=../search_result.php?search_txt=erbb2>ErbB2</a>, -3 -4 or <a href=../search_result.php?search_txt=her2>HER2</a>, -3 -4. It binds to Epidermal Growth Factor (EGF), <a href=../search_result.php?search_txt=TGFa>Transforming Growth Factor-a</a> (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head/neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

IHC (FFPE): 0.5-1 ug/ml for 30 minutes at RT (1) Flow Cytometry: 0.5-1 ug/million cells in 0.1ml IF: 1-2 ug/ml The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the EGFR antibody to be titered up or down for optimal performance.<p>1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.

Type: Primary
Antigen: EGF R
Clonality: Monoclonal
Clone: GFR450
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2a, kappa
Reactivity: Human
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