Anti-CD8A Rabbit Polyclonal Antibody

Supplier: ProSci
33-088
76193-838EA 628.58 USD
76193-838
Anti-CD8A Rabbit Polyclonal Antibody
Antibodies
CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha-beta) or as a homodimer (CD8 alpha-alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so antibody to CD8 is generally used in conjunction with antibody to CD4. CD8 alpha antibody is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

Flow Cytometry: 1-2 ug/million cells IF: 1-2 ug/ml The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the antibody to be titered up or down for optimal performance.

Type: Primary
Antigen: CD8A
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human
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