AZD-7762

Synonyms: (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide

9414-25 9414-5
76022-106EA 391.11 USD
76022-106 76022-104
AZD-7762
AZD-7762

AZD7762 is a potent, ATP-competitive, reversible, checkpoint kinase inhibitor with IC₅₀s at 5 nM and <10 nM for Chk1 and Chk2, respectively


AZD 7762 abrogates DNA damage-induced S and G2 checkpoints with an EC₅₀ value of 10 nM and potentiates the efficacy of DNA-damage repair prohibitive agents, gemcitabine and topotecan, both in vitro and in various tumor xenografts by modulating downstream checkpoint pathway proteins.

Formula: C₁₇H₁₉FN₄O₂S
MW: 362,42 g/mol
MDL Number: MFCD12406007
CAS Number: 860352-01-8
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