AZD-7762
Synonyms:
(S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide
9414-25
9414-5
76022-106EA
391.11
USD
76022-106
76022-104
AZD-7762
AZD-7762
AZD7762 is a potent, ATP-competitive, reversible, checkpoint kinase inhibitor with IC₅₀s at 5 nM and <10 nM for Chk1 and Chk2, respectively
AZD 7762 abrogates DNA damage-induced S and G2 checkpoints with an EC₅₀ value of 10 nM and potentiates the efficacy of DNA-damage repair prohibitive agents, gemcitabine and topotecan, both in vitro and in various tumor xenografts by modulating downstream checkpoint pathway proteins.
Formula:
C₁₇H₁₉FN₄O₂S MW: 362,42 g/mol |
MDL Number:
MFCD12406007 CAS Number: 860352-01-8 |
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