Cyclopamine , EZSolution™

2545-5
76020-938EA 239.32 USD
76020-938
Cyclopamine , EZSolution™
Cyclopamine

Cyclopamine blocks activation of the Hedgehog response pathway associated with mutations that either activate the proto-oncogene Smoothened (Smo) or inactivate the tumour suppressor Patched (Ptch) both of which encode multipass transmembrane proteins.  Furthermore, it has been demonstrated that the inhibitory effect of cyclopamine results from its direct binding to the Smo heptahelical protein bundle

Formula: C₂₇H₄₁NO₂
MDL Number: MFCD09878269
CAS Number: 4449-51-8
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