NSC 405020

Synonyms: 3,4-Dichloro-N-(pentan-2-yl)benzamide

2682-5 2682-25
76021-456EA 344.42 USD
76021-456 76021-454
NSC 405020
NSC 405020

NSC-405020 is a membrane type-I matrix metalloproteinase (MT1-MMP) inhibitor that specifically targets the hemopexin (PEX) domain rather than the catalytic domain of MT1-MMP (IC₅₀ >100 μmol/L)


It does not inhibit the catalytic activity of MT1-MMP or MMP-2. NSC-405020 directly interacts with and binds to PEX in a vicinity of Met-328, Arg-330, Asp-376, Met-22 and Ser-470 of the druggable pocket in the full-length MT1-MMP structure, which affects the conformation and flexibility of blades I to IV of the β-propeller resulting in the decrease of the PEX-dependent homodimerization of cellular MT1-MMP.

Formula: C₁₂H₁₅Cl₂NO
MW: 260.1596 g/mol
Storage Temperature: Freezer
MDL Number: MFCD02006898
CAS Number: 7497-07-6
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