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IWP-4, Biovision Inc

Supplier: BioVision
IWP-4 is a potent inhibitor of Wnt production that blocks Wnt pathway activity in vitro (IC₅₀ = 25 nM). IWP-4 inactivates Porcupine (porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. At 5 μM, IWP-4 has been shown to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 receptor and the scaffold protein Dishevelled, preventing the accumulation of β-catenin. IWP-4 has been used to induce cardiomyocyte differentiation from human pluripotent stem cells.

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Size Storage Temperature Package Supplier No. VWR Catalog Number Unit Price Quantity
1 mg -20°C Plastic vials 2650-1 76021-360 Each (1mg) Retrieving Restricted
5 mg -20°C Plastic vials 2650-5 76021-362 Each (5mg) Retrieving Restricted
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CAS No. 686772-17-8
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