4-(3-Pyridin-2-yl-1H-pyrazol-4-yl)quinoline

Synonyms: 4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)quinoline

2646-5 2646-1
76021-346EA 332.74 USD
76021-346 76021-344
4-(3-Pyridin-2-yl-1H-pyrazol-4-yl)quinoline
4-(3-Pyridin-2-yl-1H-pyrazol-4-yl)quinoline

LY364947 is a selective inhibitor of TGF-β RI (TGFR-I, TβR-I, ALK-5), with an IC₅₀ value of 59 nM. LY364947 only weakly inhibits TGF-β RII (IC₅₀ = 400 nM), p38 MAPK (IC₅₀ = 740 nM), and mixed lineage kinase-7 (MLK-7; IC₅₀ = 1,400 nM).It inhibits TGF-β-induced cell growth (IC₅₀ = 89 nM) in NIH 3T3 mouse fibroblasts and TGF-β-directed Smad phosphorylation, synthesis of fibronectin, PAI-1 and uPA protein, and matrigel invasion in MDA-MB-231 cells.

Formula: C₁₇H₁₂N₄
MW: 272.31 g/mol
Storage Temperature: Freezer
MDL Number: MFCD00800758
CAS Number: 396129-53-6
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