LGK974

Supplier: BioVision

Synonyms: 2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide

AB285404-1MG AB285404-5MG
76021-340EA 191.52 USD
76021-340 76021-342
LGK974
LGK974

LGK-974 is a potent and specific inhibitor of Porcupine (porcn), a Wnt-specific acyltransferase (IC₅₀ = ~0.4 nM)


GK974 potently inhibits Wnt signaling, has strong efficacy in rodent tumor models, and is well-tolerated. In addition, head and neck cancer cell lines with loss-of-function mutations in the Notch signaling pathway have a high response rate to LGK974.

Formula: C₂₃H₂₀N₆O
MW: 396,44 g/mol
Storage Temperature: Freezer
MDL Number: MFCD27501026
CAS Number: 1243244-14-5
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