LGK974
Supplier: BioVision
Synonyms:
2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide
AB285404-1MG
AB285404-5MG
76021-340EA
191.52
USD
76021-340
76021-342
LGK974
LGK974
LGK-974 is a potent and specific inhibitor of Porcupine (porcn), a Wnt-specific acyltransferase (IC₅₀ = ~0.4 nM)
GK974 potently inhibits Wnt signaling, has strong efficacy in rodent tumor models, and is well-tolerated. In addition, head and neck cancer cell lines with loss-of-function mutations in the Notch signaling pathway have a high response rate to LGK974.
Formula:
C₂₃H₂₀N₆O MW: 396,44 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD27501026 CAS Number: 1243244-14-5 |
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