GSK429286A ≥98% (by HPLC)
Supplier: BioVision
Synonyms:
RHO-15
, GSK429286
, N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide
, 4-[4-(Trifluoromethyl)phenyl]-N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide
GSK429286A is a potent and selective Rho-Kinase (ROCK) inhibitor (IC₅₀ = 14 and 63 nM for ROCK1 and ROCK2, respectively). ROCK inhibitors have been found to prevent apoptosis, as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency.
- Appearance: White solid
Formula:
C₂₁H₁₆F₄N₄O₂ MW: 432.4 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD16618404 CAS Number: 864082-47-3 |
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