AM 580 ≥98%

Synonyms: 4-​​[[(5,​​6,​​7,​​8-​​tetrahydro-​​5,​​5,​​8,​​8-​​tetramethyl-​​2-​​naphthalenyl)​carbonyl]​amino]​-​benzoic acid4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamido)benzoic acidRO 40-6055CD336NSC 608001

2635-1 2635-5
76021-310EA 75.89 USD
76021-310 76021-312
AM 580 ≥98%
AM 580

AM580 is an analog of Retinoic acid (Cat. No. 2218) that acts as aretinoic acid receptor agonist that is selective for RARα (Kd = 8 nM; AC₅₀ = 0.36 nM) compared to RARβ (Kd = 131 nM; AC₅₀ = 24.6 nM) and RARγ (Kd = 450 nM; AC₅₀ = 27.9 nM). It displays greater specific binding to RARα compared to retinoic acid which exhibits little selectivity across RARα, β, or γ. AM580 has been used in combination with the GSK3β inhibitor CHIR99021 (Cat. No.1677) to efficiently induce differentiation of human induced pluripotent stem cells into immediate mesoderm.

Formula: C₂₂H₂₅NO₃
MW: 351.44 g/mol
Storage Temperature: Freezer
MDL Number: MFCD00673916
CAS Number: 102121-60-8
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