I-BET762 ≥98% (by HPLC)
Synonyms:
2-((4S)-6-(4-Chlorophenyl)-8-methoxy-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide
, GSK525762
, (4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide
I-BET762 (GSK525762) is a highly potent, selective and cell-permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4 (IC₅₀ of ~35 nM). It inhibits myeloma cell proliferation and suppresses the production of proinflammatory proteins by macrophages and blocks acute inflammation.
- Appearance: Off-white solid
Formula:
C₂₂H₂₂ClN₅O₂ MW: 423.9 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD22417091 CAS Number: 1260907-17-2 |
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