Galiellalactone ≥90%

Supplier: BioVision

Synonyms: NSC-645020(7bS)-​5,​5aR,​6,​7,​7aR,​7b-​hexahydro-​7b-​hydroxy-​4S-​methyl-​indeno[1,​7-​bc]furan-​2(4H)-​one

AB145647-100UG AB145647-500UG
76021-262EA 482.63 USD
76021-262 76021-264
Galiellalactone ≥90%
Galiellalactone

Galiellalactone is a fungal metabolite that inhibits IL-6-mediated JAK/STAT signal transduction in HepG2 cells (IC₅₀ = 0.25-0.5 μM). The selectivity of this compound is achieved by its ability to block the binding of activated STAT3 dimers to their DNA binding sites without affecting phosphorylation of the STAT3 transcription factor.  At 10-50 μM, galiellalactone exhibits dose-dependent growth inhibitory effects on prostate cancer stem cell-like cells expressing active STAT3, suggesting it may be a useful therapeutic approach to control JAK/STAT signaling.


  • Appearance: A white lyophilized solid

Formula: C₁₁H₁₄O₃
MW: 194.23 g/mol
Storage Temperature: Freezer
CAS Number: 133613-71-5
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