CAL-101

Synonyms: (S)-2-(1-((9H-Purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-oneIdelalisibGS-1101

2613-25 2613-5
76021-222EA 87.57 USD
76021-222 76021-224
CAL-101
CAL-101

CAL-101 is a cell-permeable inhibitor of the PI3K catalytic subunit p110δ (IC₅₀ = 2.5 nM) that displays 40- to 300-fold selectivity against other PI3K class I enzymes (IC₅₀s = 820, 565, and 89 nM for p110α, β, and γ, respectively)


It has also been shown to inhibit the chemotaxis of chronic lymphocytic leukemia cells and to downregulate the secretion of chemokines triggered by B-cell receptor signaling.

Formula: C₂₂H₁₈FN₇O
MW: 415,42 g/mol
Storage Temperature: Freezer
MDL Number: MFCD19443647
CAS Number: 870281-82-6
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