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FLI-06, Biovision Inc

Supplier: BioVision
A potent Notch signaling (EC₅₀ = 2.3 µM) as well as the early secretory pathway inhibitor. FLI-06 leads to a disruption of the Golgi by a mechanism different from Brefeldin A (Cat. No. 1560) or other known secretion inhibitors. FLI-06 blocks secretion by inhibiting the recruitment of cargo to ER exit sites, but not the formation of COPII vesicles. FLI-06 transforms the tubular regions of the ER to large sheets, suggesting that regions of high curvature at ER exit sites are essential for the recruitment of cargo.

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Size Storage Temperature Package Supplier No. VWR Catalog Number Unit Price Quantity
25 mg -20 ̊C Plastic vials 2603-25 76021-192 Each (25mg) Retrieving Restricted
5 mg -20 ̊C Plastic vials 2603-5 76021-190 Each (5mg) Retrieving Restricted
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CAS No. 313967-18-9
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