Myriocin

Synonyms: ISP-1

2567-5 2567-25
76021-016EA 122.58 USD
76021-016 76021-018
Myriocin
Myriocin

A fungal metabolite with potent immunosuppressant activity that is 10-100 fold more compared to Cyclosporin A (Cat


No. 1522). It inhibits serine palmitoyltransferase (Ki = 0.28 nM) blocking the synthesis of ceramide. It was found to suppress melanoma cell proliferation by cell cycle arrest at the G 2/M phase through decreased sphingolipid levels and increased p53 and p21 (waf1/cip1) expression.

Storage Temperature: Freezer
MDL Number: MFCD01632772
CAS Number: 35891-70-4
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