CID-755673
Synonyms:
7-Hydroxy-2,3,4,5-tetrahydro-1H-benzofuro[2,3-c]azepin-1-one
CID-755673 is a selective small molecule inhibitor of protein kinase D (PKD) (IC₅₀s = 182, 280, 227 nM for PKD1, 2, and 3, respectively)
It exhibits higher selectivity for PKD over Akt, polo-like kinase 1, CDK activating kinase, CAMKII and three different PKC isoforms (IC₅₀s range from 15 to > 50 µM). At 25 µM, CID-755673 has been shown to inhibit prostate cancer cell proliferation, cell migration, and invasion.
Formula:
C₁₂H₁₁NO₃ MW: 217.2206 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD03828155 CAS Number: 521937-07-5 |
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