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Anti-PML Rabbit Polyclonal Antibody

Supplier: FITZGERALD INDUSTRIES INTNL MS
70R-7965
PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. PML localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus.

Optimal conditions to be determined by the end user

Type: Primary
Antigen: PML
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity:




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
50 µg 70R-7965 102030-898 Each (50µG) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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VWR will not lift restrictions for residential shipping addresses.

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SPECIFICATIONS

Antigen Symbol PML
Conjugation Unconjugated
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Western Blot Yes
Concentration 1 mg/ml
Format Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.
Immunogen PML antibody was raised in rabbit using the C terminal of PML as the immunogen
Storage Temperature Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.
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