CD437
Synonyms:
6-(3-(Adamantan-1-yl)-4-hydroxyphenyl)-2-naphthoic acid
CD437 is the adamantyl arotinoid of the retinoid-related molecule family that acts as a selective agonist of retinoic acid receptor (RAR)γ (Kds = 6.5 μM, 2.5 μM, and 77 nM for RARα, β, and γ, respectively)
CD437 is cytotoxic to the acute myeloid leukemia cell line NB4 (EC₅₀ = 0.17 μM), inducing DNA damage by producing DNA double strand breaks. CD437 also induces cell cycle arrest and apoptosis in various other cancer cells including melanoma, breast, non-small lung, and prostate cancer cells through RAR-dependent and -independent signaling pathways. Treatment of mouse embryonic fibroblasts (MEFs) with CD437 early in the reprogramming process significantly increases reprogramming efficiency up to 20-fold.
Formula:
C₂₇H₂₆O₃ MW: 398.4936 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD03106506 CAS Number: 125316-60-1 |
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