CD437

Synonyms: 6-(3-(Adamantan-1-yl)-4-hydroxyphenyl)-2-naphthoic acid

2636-25 2636-5
76021-314EA 157.61 USD
76021-314 76021-316
CD437
CD437

CD437 is the adamantyl arotinoid of the retinoid-related molecule family that acts as a selective agonist of retinoic acid receptor (RAR)γ (Kds = 6.5 μM, 2.5 μM, and 77 nM for RARα, β, and γ, respectively)


CD437 is cytotoxic to the acute myeloid leukemia cell line NB4 (EC₅₀ = 0.17 μM), inducing DNA damage by producing DNA double strand breaks. CD437 also induces cell cycle arrest and apoptosis in various other cancer cells including melanoma, breast, non-small lung, and prostate cancer cells through RAR-dependent and -independent signaling pathways. Treatment of mouse embryonic fibroblasts (MEFs) with CD437 early in the reprogramming process significantly increases reprogramming efficiency up to 20-fold.

Formula: C₂₇H₂₆O₃
MW: 398.4936 g/mol
Storage Temperature: Freezer
MDL Number: MFCD03106506
CAS Number: 125316-60-1
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