BML-286 ≥98% (by HPLC)

Supplier: Enzo Life Sciences

BML-WN113-0010
76002-428EA 128.48 USD
76002-428
BML-286 ≥98% (by HPLC)
BML-286

Disrupts Wnt signaling


Cell-permeable compound that disrupts Wnt signaling by binding to the PDZ domain of dishevelled (Kd=10.6 µM). Blocked Wnt3a-induced transcription activity and was able to supress the Wnt pathway-dependent growth of prostate cancer PC-3 cells (IC50=12.5 µM). BML-286 was also capable of supressing Wnt signaling in vivo (Xenopus embryo and mouse hyaloids vessel system).

CAS Number: 294891-81-9

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