FH535 ≥98% (by TLC)
Supplier: Enzo Life Sciences
Synonyms:
2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulphonamide
, 2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide
Inhibits the recruitment of the co-activators β-catenin and GRIP1
Antagonizes Wnt/β-catenin/Tcf-mediated transcription as well as PPARγ and δ activity. Able to inhibit the recruitment of the co-activators β-catenin and GRIP1, both of which are activators for both pathways. FH535 was toxic (LC50=5 to 15µM) to 10 of 12 carcinoma cell lines tested. A unique tool to study the relationship between Wnt and PPAR signaling pathways.
Formula:
C₁₃H₁₀Cl₂N₂O₄S MW: 361,2 g/mol |
MDL Number:
MFCD01212888 CAS Number: 108409-83-2 |
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