XAV939 ≥98% (by TLC)

Supplier: Enzo Life Sciences

Synonyms: 2-(4-(Trifluoromethyl)phenyl)-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one

BML-WN100-0025 BML-WN100-0005
76002-190EA 81.01 USD
76002-190 76002-192
XAV939 ≥98% (by TLC)
XAV939

PARP5a inhibitor


Potent inhibitor of Tankyrase 1 (IC50=11nM) and Tankyrase 2 (IC50=4nM). Inhibition of tankyrase promotes stabilization of axin resulting in β-catenin degradation and Wnt signalling disruption. Inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyogenic development in mesoderm progenitor cells.

Formula: C₁₄H₁₁F₃N₂OS
MW: 312.3102 g/mol
MDL Number: MFCD16879017
CAS Number: 284028-89-3
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