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Tigecycline, AdipoGen Life Sciences

Supplier: ADIPOGEN CORP MS
Tigecycline is a glycylcycline antibiotic, a new class of antibiotics derived from tetracycline, with broad-spectrum activity.

  • Inhibits protein translation in bacteria
  • In vitro and in vivo activity against bacterial pathogens
  • Developed in response to the growing prevalence of antibiotic resistance in bacteria

Tigecycline is a glycylcycline antibiotic, a new class of antibiotics derived from tetracycline, with broad-spectrum activity. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance, namely resistance mediated by acquired efflux pumps and/or ribosomal protection. Glycylcycline antibiotics have a similar mechanism of action as tetracycline antibiotics. Both classes of antibiotics inhibit protein translation in bacteria by binding to the 30S ribosomal subunit and blocking entry of amino-acyl tRNA molecules into the A site of the ribosome. This prevents incorporation of amino acid residues into elongating peptide chains. Tigecycline carries a glycylamido moiety attached to the 9-position of minocycline. The substitution pattern is not present in any naturally occurring or semisynthetic tetracycline and imparts certain microbiologic properties to tigecycline. Accordingly, tigecycline has demonstrated in vitro and in vivo activity against a broad spectrum of bacterial pathogens. However, the glycylcyclines appear to bind more effectively than the tetracyclines. Tigecycline was developed in response to the growing prevalence of antibiotic resistance in bacteria such as Staphylococcus aureus and Acinetobacter baumanii.



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Description Size Packaging Supplier No. VWR Catalog Number Unit Price Quantity
Tigecycline 50 mg Plastic vial SYN-3024-M050 102993-000 Each (50mg) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

Tigecycline 5 mg Plastic vial SYN-3024-M005 102992-996 Each (5mg) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

Tigecycline 10 mg Plastic vial SYN-3024-M010 102992-998 Each (10mg) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

Tigecycline 1 mg Plastic vial SYN-3024-M001 102992-994 Each (1mg) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

restricted In order to process your orders without delay, we request that you provide the required business documentation to purchase this product.

To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email CMD_NA@vwr.com or fax 484.881.5997 referencing your VWR account number . Acceptable forms of identification are:

  • State issued document with your organization's Federal Tax ID Number
  • State issued document with your organization's Resale Tax ID Number
  • City or County issued Business License
  • State Department of Health Services License
  • Any other ID issued by the State that includes the business name and address

* Please note if your account is within the State of California two of these pieces of identification will be required.
VWR will not lift restrictions for residential shipping addresses.

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SPECIFICATIONS

Formulation Solid
Molecular weight 585.7
Purity 95%
Solubility Soluble in DMSO. Slightly soluble (1mg/mL) in ethanol
Storage Conditions Freezer
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