Chlorpromazine hydrochloride

Supplier: MP BIOMEDICALS (FKA ICN BIOMED
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Synonyms: 2-Chloro-10-[3-(dimethylamino)-1-propyl]phenothiazine Hydrochloride

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IC19032680EA 1012.46 USD
IC19032680 IC19032625 IC19032605
Chlorpromazine hydrochloride
Chlorpromazine hydrochloride

Chlorpromazine Hydrochloride is a phenothiazine antipsychotic; a D2 and H1 antagonist. It inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase and is reported to uncouple and inhibit oxidative phosphorylation at 10-3 - 10-4 M. It is possibly a photogenotoxic agent in humans. Helps to induce hypothermia in mice in the dose range of 12.5 -100 mg/kg.
Chlorpromazine demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes.

Phenothiazine antipsychotic; D2 dopamine receptor antagonist, H1 histamine receptor antagonist; inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase.


Chlorpromazine hydrochloride is a substitute for benzidine, o-dianisidine, and o-tolidine in the determination of microquantities of hemoglobin and peroxidase.

Formula: C₁₇H₁₉ClN₂S
MW: 355.32 g/mol
Melting Pt: 194…199 °C
Storage Temperature: Ambient
MDL Number: MFCD00012654
CAS Number: 69-09-0
EINECS: 200-701-3
UN: 2811
ADR: 6.1,I
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Specification Test Results

Physical Appearance White Powder
Extinction Coefficient EmM= 31.5 (0.12 M HCl) (Lit.)
Loss on Drying ≤1.0%
Solubility Soluble in water (50 mg/mL - clear, colorless to faint yellow-grey solution), methanol, ethanol, chloroform; practically insoluble in ether, benzene.

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