ADIPSYN-3023

SYN-3023-M005 SYN-3023-M050 SYN-3023-M010 SYN-3023-M001
102992-988EA 96.92 USD
102992-988 102992-986 102992-990 102992-992
ADIPSYN-3023
Exemestane (6-methylenandrosta-1,4-diene-3,17-dione; FCE 24304) is an orally active irreversible aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation. Exemestane inhibits human placental and rat ovarian aromatase with IC50 values of 30nM and 40nM, respectively.
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