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URMC-099 ≥95% (by HPLC)

Supplier: ADIPOGEN CORP MS

Synonyms: 3-(1H-Indol-5-yl)-5-(4-(4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3- b]pyridine

SYN-1211-M005 SYN-1211-M010 SYN-1211-M050 SYN-1211-M001

102992-812EA 149.54 USD

102992-812 102992-816 102992-814 102992-818

URMC-099 ≥95% (by HPLC)

URMC-099

Inhibition of mixed lineage kinase 3 (MLK-3) is a potential strategy for the treatment of Parkinson's disease and HIV-1 associated neuro-cognitive disorders (HAND), requiring an inhibitor that can achieve significant brain concentration levels. URMC-099 is an orally bioavailable MLK-3 inhibitor with excellent brain exposure in mouse PK models and minimal interference with key human CYP450 enzymes or hERG channels. URMC-099 inhibits multiple kinase pathways, including MLK-3 (14nM) and leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (11nM).

Formula: C₂₇H₂₇N₅
MW: 421.5 g/mol
Storage Temperature: Freezer

MDL Number: MFCD28168077
CAS Number: 1229582-33-5

Specification Test Results

Purity	95% (HPLC)
Appearance/Color	Solid.
Solubility	Soluble in DMSO or water.

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