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SAR-020106 ≥95%

Supplier: ADIPOGEN CORP MS

SYN-1189-M010 SYN-1189-M001 SYN-1189-M005

102992-668EA 576 USD

102992-668 102992-666 102992-670

SAR-020106 ≥95%

SAR-020106

SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3nM on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55nM in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion. Biomarker studies have shown that SAR-020106 inhibits cytotoxic drug-induced autophosphorylation of CHK1 at S296 and blocks the phosphorylation of CDK1 at Y15 in a dose-dependent fashion both in vitro and in vivo.

Formula: C₁₉H₁₉ClN₆O
Storage Temperature: Refrigerator

CAS Number: 1184843-57-9

Specification Test Results

Purity	95%
Appearance/Color	Solid.
Solubility	Soluble in DMSO.

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