Bentamapimod ≥95%

Supplier: ADIPOGEN CORP MS

Synonyms: 2-(Benzo[d]thiazol-2-yl)-2-(2-((4-(morpholinomethyl)benzyl)oxy)pyrimidin-4-yl)acetonitrileAS-602801

SYN-1147-M010 SYN-1147-M005 SYN-1147-M001
102992-370EA 688.15 USD
102992-370 102992-368 102992-366
Bentamapimod ≥95%
Bentamapimod

Bentamapimod (AS602801) is a novel and orally active c-Jun-N-Terminal Kinase Inhibitor highly specific for JNK kinases. The inhibitor Bentamapimod (AS602801) is a potent anti-inflammatory agent which has been shown to reduce the disease burden in several pre-clinical models for endometriosis, and has the potential to be effective in addressing the causes of post-operative abdominal adhesions. Pre-clinical data have demonstrated Bentamapimod to be an effective anti-inflammatory compound with anti-fibrotic properties. Bentamapimod (AS602801) showed good bioavailability in rats (F=50%). It does cross the blood brain barrier, with 98% brain penetration the drug has been well tolerated so far. Bentamapimod (AS602801) is a potent and selective JNK inhibitor with therapeutic potential in MS and fibrosis as well.

Formula: C₂₅H₂₃N₅O₂S
MW: 457.6 g/mol
Storage Temperature: Freezer
MDL Number: MFCD08272350
CAS Number: 848344-36-5

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Specification Test Results

Purity 95%
Appearance/Color Solid.
Solubility Soluble in DMSO.

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