AT9283 ≥95%

Supplier: ADIPOGEN CORP MS

Synonyms: 1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea

SYN-1011-M001 SYN-1011-M010 SYN-1011-M050 SYN-1011-M005
102991-334EA 373.85 USD
102991-334 102991-336 102991-330 102991-332
AT9283 ≥95%
AT9283

Aurora kinases play a key role in the regulation of mitosis and in recent years have become attractive targets for the treatment of cancer. AT9283 is a powerful inhibitor of Aurora A and B kinases as well as several other important kinases including JAK2 and Abl (T315I). AT9283 has also been shown effective in mouise xenograft models and has been studied as a possible clinical candidate. Effective IC(50) doses for Aurora kinases are in the low 2-3nM range, and inhibition of a number of other kinases including JAK2 has been reported at 1-10nM.

Formula: C₁₉H₂₃N₇O₂
MW: 381.4 g/mol
Storage Temperature: Freezer
MDL Number: MFCD12031513
CAS Number: 896466-04-9

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Specification Test Results

Purity 95%
Appearance/Color Solid.
Solubility Soluble in DMSO or ethanol.

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