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N-Dodecanoyl-L-homoserine lactone ≥98% (by NMR)

Supplier: ADIPOGEN CORP MS

Synonyms: N-[(3S)-Tetrahydro-2-oxo-3-furanyl]-dodecanamide

CDX-D0335-M005 CDX-D0335-M050

102989-792EA 88.62 USD

102989-792 102989-794

N-Dodecanoyl-L-homoserine lactone ≥98% (by NMR)

N-Dodecanoyl-L-homoserine lactone

N-Dodecanoyl-L-homoserine lactone (C12-HSL) is a small diffusible signalling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism in bacteria. In addition to regulating bacterial functions, C12-HSL activates NF-kappaB in RAW 264.7 macrophages, increasing the expression of TNF-alpha, interleukin-1beta (IL-1beta) and IL-8, while other lactones do not. In addition, C12-HSL alters cell cycling and metabolism of human keratinocyte (HaCaT) cells. It is important to note that C12-HSL is distinct from N-3-oxo-dodecanoyl-L-homoserine lactone, which is produced at different times in biofilm development and has different cellular effects.

Formula: C₁₆H₂₉NO₃
MW: 283.4 g/mol
Storage Temperature: Refrigerator

CAS Number: 137173-46-7

Specification Test Results

Source/Host	Synthetic.
Purity	98% (NMR)
Appearance/Color	White powder.
Solubility	Soluble in DMSO and dimethylformamide (approx. 30mg/ml).

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