Okadaic acid potassium salt ≥98% (by HPLC), high purity

Danger

Synonyms: 9,10-deepithio-9,10-didehydroacanthifolicin potassium saltHalochondrine A potassium saltOA potassium salt

AG-CN2-0060-C100
102987-192EA 304.62 USD
102987-192
Okadaic acid potassium salt ≥98% (by HPLC), high purity
Okadaic acid potassium salt

Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0.2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization.

Formula: C₄₄H₆₇O₁₃·K
MW: 843.11 g/mol
Storage Temperature: Freezer
MDL Number: MFCD00214356
CAS Number: 209266-79-5
UN: 3462
ADR: 6.1,III

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Specification Test Results

Source/Host Isolated from Prorocentrum concavum. Salt form generated in aqueous potassium hydroxide-methanol solution.
Purity 98% (HPLC)
Appearance/Color White to off-white solid.
Solubility Soluble in DMSO, ethanol, methanol, acetone, ethyl acetate or distilled water. Dissolve first in organic solvent before diluting in water.

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