5-Fluorocytosine

Supplier: ADIPOGEN CORP MS

Synonyms: 4-Amino-5-fluoro-2-pyrimidinol 5-FC Flucytosine

CDX-F0077-G005 CDX-F0077-G001
102989-986EA 210.46 USD
102989-986 102989-988
5-Fluorocytosine
5-Fluorocytosine

Fluorinated pyrimidine analog. Antimycotic prodrug that is converted by cytosine deaminase to 5-fluorouracil (a widely used cytotoxic drug) and further metabolized to fluorinated ribo- and deoxyribonucleotides. Inhibits DNA and RNA synthesis and interfers with ribosomal protein synthesis. Displays antifungal and antitumor activity. Lately with the development of gene therapy, it has been introduced as a prodrug in combination with the cytosine deaminase suicide gene as antitumor compound, significantly improving survival and reducing tumor size in selected tumors.

Formula: C₄H₄FN₃O
MW: 129.09 g/mol
MDL Number: MFCD00006035
CAS Number: 2022-85-7

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