Dihydrorhodamine 123

Supplier: ADIPOGEN CORP MS

Synonyms: 2-(3,6-Diamino-9H-xanthene-9-yl)-benzoic acid methyl ester

CDX-D0134-M125 CDX-D0134-M010 CDX-D0134-M002
102987-892EA 2500.62 USD
102987-892 102987-890 102987-888
Dihydrorhodamine 123
Dihydrorhodamine 123

Cell-permeable non-fluorescent reactive oxygen species (ROS) indicator. Passively diffuses across membranes where it is oxidized by peroxynitrite to rhodamine 123 which localizes in the mitochondria and exhibits green fluorescence (Ex/Em wavelengths of 500 and 536 nm). Used to investigate reactive oxygen intermediates produced by human and murine phagocytes, activated rat mast cells and cultured endothelial cells. In addition, it has been used together with Fura Red calcium indicator to simultaneously measure oxidative bursts and Ca2+ fluxes in monocytes and granulocytes. Dihydrorhodamine 123 has been shown to be a more sensitive probe than H2DCFDA for detecting granulocyte respiratory bursts.

Formula: C₂₁H₁₈N₂O₃
MW: 346.386 g/mol
CAS Number: 109244-58-8

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