(S)-(+)-Camptothecin ≥98% (by HPLC)

Supplier: ADIPOGEN CORP MS
Danger

Synonyms: 4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

AG-CN2-0463-M250 AG-CN2-0463-M050
102988-358EA 34.62 USD
102988-358 102988-360
(S)-(+)-Camptothecin ≥98% (by HPLC)
(S)-(+)-Camptothecin

Potent anticancer compound. Cell permeable potent DNA topoisomerase I (Topo I) complex inhibitor. Potent apoptosis inducer. Binds reversibly to the DNA topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, consequently depleting cellular topoisomerase I. Prevents DNA re-ligation and therefore causes DNA damage which results in apoptosis. Inhibits mitochondrial topoisomerase I (mtTop1). Blocks the cell cycle at low dose and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes. Antiprotozoal and antimalarial compound. Inhibitor of HIV replication and of other viruses. Suppresses nitric oxide (NO) biosynthesis. Shown to suppress TNF-alpha-induced expression of the inflammasome and cyclooxygenase 2 (COX-2).

Formula: C₂₀H₁₆N₂O₄
MW: 348.36 g/mol
Storage Temperature: Refrigerator
MDL Number: MFCD00081076
CAS Number: 7689-03-4
UN: 2811
ADR: 6.1,III

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Specification Test Results

Source/Host Isolated from Camptotheca acuminata.
Purity 98% (HPLC)
Appearance/Color White solid.
Solubility Soluble in DMSO, DMF or MeOH. Insoluble in water

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