cis-Platin ≥98% (by HPLC), Calbiochem®
Supplier: MilliporeSigma
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Danger
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Synonyms:
cis-Diaminodichloroplatinum(II)
, cis-Diamminedichloroplatinum (II)
, cis-Diamineplatinum(II) dichloride
, Platinol
, cis-Dichlorodiammine platinum(II)
, Cisplatin
A platinum coordination complex with potent antineoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation.
It is highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/mL mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.
Formula:
H₆Cl₂N₂Pt MW: 300.05 g/mol Density: 3.738 g/cm³ (20 °C) Storage Temperature: Ambient |
MDL Number:
MFCD00011623 CAS Number: 15663-27-1 EINECS: 239-733-8 UN: 3288 ADR: 6.1,II |
Specification Test Results
Appearance | Yellow solid |
Purity (by HPLC) | ≥98% |
Solubility | DMSO (10 mg/mL), H₂O with 154 mM NaCl (1 mg/mL), or PBS with 140 mM NaCl (1 mg/mL) |
Storage | Store at 2 to 8 °C |
Stability | Unstable in solution; reconstitute just prior to use. |
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