Ns3694, Calbiochem®
Supplier: MilliporeSigma
The Apoptosis Inhibitor II, NS3694, controls the biological activity of Apoptosis
- CAS number: 426834-38-0
- Form: White solid
- Hill Formula: C₁₅H₁₀ClF₃N₂O₃
- Chemical formula: C₁₅H₁₀ClF₃N₂O₃
- Primary Target: Apoptosome complex formation
- Primary Target IC50: 50 µM completely blocks TNF-α-induced death in MCF-casp3 cells
- Purity: ≥95% by HPLC
- Storage: +2°C to +8°C
A cell-permeable diarylurea compound that specifically prevents the active ~700-kDa apoptosome complex formation triggered by cytochrome c release, thus blocking apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Exhibits no effect on apoptosome-independent caspase activation and cell death induced by FasL. Inhibits neither cytochrome c release nor the enzymatic activity of caspases.
This small molecule/inhibitor is primarily used for Cancer applications.
MW:
358.70 g/mol |
MDL Number:
MFCD00249000 CAS Number: 426834-38-0 |
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