CD105, also known as endoglin, is a disulfide-linked type II transmembrane homodimer that is predominantly expressed on vascular endothelial cells. It is also found on pre-erythroblasts, macrophages, and lymphoid and myeloid leukemic cells. Both mouse and human CD105 exhibit >70% sequence homology in their cytoplasmic domains with type III transforming growth factor β (TGFβ) receptor. CD105 has been shown to be one of several receptors for the various isoforms of TGFβ which in turn is one of a family of proteins involved in regulation of cell differentiation, migration of cells, and control of the immune response.
Type: Primary
Antigen: CD105
Clonality: Monoclonal
Clone: MJ7/18
Conjugation: Unconjugated
Epitope:
Host: Rat
Isotype: IgG2a
Reactivity: Mouse