Anti-Ly-6A/E Rat Monoclonal Antibody (Biotin) [clone: D7]

Supplier: Southern Biotechnology
100243-708EA 320.38 USD
Anti-Ly-6A/E Rat Monoclonal Antibody (Biotin) [clone: D7]
Ly-6A/E, also known as Sca-1, is a member of the Ly-6 multigene family of type V glycophosphatidylinositol-anchored cell surface proteins. It is expressed on multipotent hematopoietic stem cells in bone marrow of mice with both the Ly-6.1 and Ly-6.2 allotypes. In the periphery, Ly-6A/E exhibits a pattern of expression which is based on differences between the two allotypes. Ly-6.1 strains (e.g., A, BALB/c, CBA, C3H/He, DBA/1, NZB) have few Ly-6A/E+ resting peripheral lymphocytes whereas Ly-6.2 strains (e.g., AKR, C57BL, C57BR, C57L, DBA/2, PL, SJL, SWR, 129) have relatively high numbers of Ly-6A/E+ lymphocytes. The expression of Ly-6A/E is dramatically upregulated in all strains upon cellular activation. Studies with the monoclonal antibody D7 suggest that Ly-6A/E may be involved in B and T lymphocyte responses and it appears that the antigen may be required for T-cell receptor-mediated T-cell activation.

Type: Primary
Antigen: Ly-6A/E
Clonality: Monoclonal
Clone: D7
Conjugation: Biotin
Host: Rat
Isotype: IgG2a
Reactivity: Mouse
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