Anti-CD62L Rat Monoclonal Antibody (Spectral Red® RPE (R-Phycoerythrin)/Cy5®) [clone: MEL-14]

Supplier: Southern Biotechnology
100243-600EA 285.08 USD
Anti-CD62L Rat Monoclonal Antibody (Spectral Red® RPE (R-Phycoerythrin)/Cy5®) [clone: MEL-14]
CD62L, also known as L-selectin, is a type I transmembrane glycoprotein with lectin-like and epidermal growth factor-like domains. It binds to sialylated oligosaccharide determinants on high endothelial venules (HEV) in peripheral lymph nodes. In the mouse, CD62L is expressed on most thymocytes and on peripheral leukocytes, including B and T lymphocytes, neutrophils, monocytes, and eosinophils. This member of the selectin family of cell adhesion molecules appears to be required for lymphocyte homing to peripheral lymph nodes and for leukocyte extravasation at sites of inflammation. Expression of CD62L on lymphocytes and neutrophils is rapidly down-regulated upon cell activation and the level of CD62L expression, along with other markers, distinguishes naive T cells from effector/memory T cells. The monoclonal antibody MEL-14 blocks in vitro binding of lymphocytes to peripheral lymph node HEV and inhibits in vivo lymphocyte extravasation into peripheral lymph nodes and the late stages of leukocyte rolling.

Type: Primary
Antigen: CD62L
Clonality: Monoclonal
Clone: MEL-14
Conjugation: Spectral Red® RPE (R-Phycoerythrin)/Cy5®
Host: Rat
Isotype: IgG2a
Reactivity: Mouse
Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR