Anti-CD154 Hamster Monoclonal Antibody (Biotin) [clone: MR1]

Supplier: Southern Biotechnology
100243-498EA 381.85 USD
Anti-CD154 Hamster Monoclonal Antibody (Biotin) [clone: MR1]
CD154, formerly known as CD40 ligand and gp39, is a type II integral membrane protein and a member of the tumor necrosis factor (TNF) family of ligands. It is an important accessory molecule in T cell-B cell costimulatory interactions and is expressed predominantly on activated CD4+ T lymphocytes. It is also present on the surface of activated Th0, Th1, and Th2 T cell clones. Its expression is transient and cyclosporin-sensitive. The MR1 monoclonal antibody binds to murine CD154 with high affinity, blocks binding to CD40, and blocks CD154 function. Administration of this antibody to mice blocks the ability to mount primary and secondary immune responses to TD antigens yet does not alter the immune response to TI antigens.

Type: Primary
Antigen: CD154
Clonality: Monoclonal
Clone: MR1
Conjugation: Biotin
Host: Hamster
Isotype: IgG
Reactivity: Mouse
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