Anti-CD40 Rat Monoclonal Antibody (Biotin) [clone: 1C10]

Supplier: Southern Biotechnology

1645-08

100243-482EA 324.31 USD

100243-482

Anti-CD40 Rat Monoclonal Antibody (Biotin) [clone: 1C10]

Antibodies

CD40 is a type I cell surface protein belonging to the tumor necrosis factor superfamily of cell surface receptors. In mice it is expressed on B lineage cells, follicular dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zone of secondary lymphoid organs. CD40 first becomes detectable on a subset of small pre-B II cells in bone marrow with the levels of CD40 expression increasing thereafter during B cell maturation. Immature B cells (IgM+IgDloB220lo) express intermediate levels of CD40, whereas mature B cells (IgM+IgDhiB220hi) express high levels. CD40 has a central role in B cell growth and differentiation, and signaling through CD40 in combination with IL-4 reportedly induces immunoglobulin isotype switching and secretion of IgE. The agonistic 1C10 antibody closely resembles gp39/CD40 ligand in its ability to stimulate proliferation of small, resting B lymphocytes in the absence of other cofactors.

Type: Primary
Antigen: CD40
Clonality: Monoclonal
Clone: 1C10
Conjugation: Biotin
Epitope:
Host: Rat
Isotype: IgG2a
Reactivity: Mouse

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