Anti-CD38 Rat Monoclonal Antibody [clone: NIMR-5]

Supplier: Southern Biotechnology

1635-01

100243-448EA 330.85 USD

100243-448

Anti-CD38 Rat Monoclonal Antibody [clone: NIMR-5]

Antibodies

Murine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR) and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR). It is expressed at high levels on the surface of peripheral B-lineage cells and at low density on germinal center B cells from unimmunized mice. It has also been reported to be expressed at moderate levels on NK cells, a proportion of peripheral T cells, and a subpopulation of thymocytes which are mostly TCRαβ+, CD4-, CD8-. Murine CD38 is also expressed by all Mac-1+ macrophages in the peritoneal cavities of unimmunized mice, but not by unstimulated bone-marrow-derived macrophages. Monoclonal antibodies to CD38 have been shown to induce B and T cell proliferation, protect B cells from apoptosis, and inhibit B lymphopoiesis.

Type: Primary
Antigen: CD38
Clonality: Monoclonal
Clone: NIMR-5
Conjugation: Unconjugated
Epitope:
Host: Rat
Isotype: IgG2a
Reactivity: Mouse

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