Anti-CD22 Rat Monoclonal Antibody (RPE (R-Phycoerythrin)) [clone: 2D6]

Supplier: Southern Biotechnology

1580-09

100243-302EA 266.77 USD

100243-302

Anti-CD22 Rat Monoclonal Antibody (RPE (R-Phycoerythrin)) [clone: 2D6]

Antibodies

CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. Its intracellular domain is phosphorylated after antigen receptor cross-linking and is involved in negative regulation of B cell activation.

Type: Primary
Antigen: CD22
Clonality: Monoclonal
Clone: 2D6
Conjugation: RPE (R-Phycoerythrin)
Epitope:
Host: Rat
Isotype: IgG1
Reactivity: Mouse

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