Anti-CD3 epsilon Hamster Monoclonal Antibody (APC (Allophycocyanin)) [clone: 145-2C11]

Supplier: Southern Biotechnology
100243-068EA 262.85 USD
Anti-CD3 epsilon Hamster Monoclonal Antibody (APC (Allophycocyanin)) [clone: 145-2C11]
CD3ε, a member of the immunoglobulin superfamily of cell surface receptors, is comprised of five invariable chains ranging in size from 16-28 kDa and is closely associated with the T cell antigen receptor (TCR). It is expressed on all T cells of all mouse strains. CD3 plays a major role in signaling during antigen recognition, leading to T-cell activation. The 145-2C11 monoclonal antibody recognizes an epitope on the 25 kDa ε chain of the CD3/TCR complex. In the presence of Fc receptor-bearing accessory cells, soluble 145-2C11 can activate primed and naïve T cell in vitro. 145-2C11 can also induce redirected lysis of specific target cells by CTL clones and it can block lysis of specific target cells by antigen-specific CTL’s. Immobilized 145-2C11 can activate both normal T lymphocytes and cloned T cell lines. Under certain conditions, T cell activation by 145-2C11 may result in apoptotic cell death.

Type: Primary
Antigen: CD3epsilon
Clonality: Monoclonal
Clone: 145-2C11
Conjugation: APC (Allophycocyanin)
Host: Hamster
Isotype: IgG
Reactivity: Mouse
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