Neomycin sulfate
Synonyms:
Fradiomycin sulphate
, Neomycin sulfate salt
, Neomycin
, (2S,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-diamino-2-(((2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-6-hydroxycyclohexyl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)tetrahydro-2H-pyran-3,4-diol sulfate
, Neomycin sulphate salt
, Fradiomycin sulfate
, (2S,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-diamino-2-(((2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-6-hydroxycyclohexyl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)tetrahydro-2H-pyran-3,4-diol sulphate
Neomycin sulfate is a broad spectrum aminoglycoside antibiotic composed of a number of related neomycin compounds including neomycin A (neamine), neomycin B (framycetin), neomycin C, and a few minor compounds found in much lower quantities.
- Acts by binding to the 30S and 50S subunits
- Miscoding and inhibiting initiation and elongation during protein synthesis
- Blocks voltage-sensitive Ca²⁺+ channels without affecting the Na⁺/Ca²⁺ antiporter in neurons
Neomycin B is the most active component in neomycin followed by neomycin C and neomycin A. This product acts by binding to the 30S and 50S subunits, causing miscoding and inhibiting initiation and elongation during protein synthesis. Neomycin also blocks voltage-sensitive Ca²⁺+ channels without affecting the Na⁺/Ca²⁺ antiporter in neurons.
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Formula:
C₂₃H₄₆N₆O₁₃·3H₂SO₄ MW: 908.87 g/mol |
MDL Number:
MFCD00150827 CAS Number: 1405-10-3 |
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