Erythromycin
Synonyms:
(-)-Erythromycin
Erythromycin is a macrolide antibiotic with a target spectrum similar to penicillin.
- Inhibits bacterial protein synthesis
- Blocks the progression of nascent polypeptide chains
- Known to potently inhibit the cytochrome P450 isoform CYP3A4
It inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. It is effective against a host of bacterial genera, including Streptococcus, Staphylococcus, and Haemophilus (MIC₉₀s range from 0.015-2.0 mg/l). Erythromycin is known to potently inhibit the cytochrome P450 isoform CYP3A4, which can affect the metabolism of numerous clinically relevant medications.
Formula:
C₃₇H₆₇NO₁₃ MW: 733.95 g/mol |
MDL Number:
MFCD00084654 CAS Number: 114-07-8 |
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