GN25 ≥98%

Synonyms: 3-​[(1,​4-​dihydro-​5,​8-​dimethoxy-​1,​4-​dioxo-​2-​naphthalenyl)thio]-​propanoic acidp53-Snail binding Inhibitor

9430-25 9430-5
75837-610EA 99.24 USD
75837-610 75836-856
GN25 ≥98%
GN25

GN25 blocks Snail binding to p53 and induces p53 expression in cancer cells in a KRas dependent manner.


  • Yields antitumoral effects
  • Notably reduce tumor size and progression
  • Significantly reduces cell proliferation in KRas mutated A549 and HCT116 cell lines


Oncogenic KRas has been shown to inhibit p53 function by inducing Snail to bind and eliminate p53 through exocytosis. At 10 μM, GN25 significantly reduces cell proliferation in KRas mutated A549 and HCT116 cell lines but not in wild type MKN-45 cells. In a xenograft mouse model, 10 mg/kg GN25 yields antitumoral effects by notably reducing tumor size and progression.

Formula: C₁₅H₁₄O₆S
MW: 322.3 g/mol
CAS Number: 1227401-27-5

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