KC7F2
Synonyms:
N,N'-(Disulphanediylbis(ethane-2,1-diyl))bis(2,5-dichlorobenzenesulphonamide)
, N,N'-(Disulfanediylbis(ethane-2,1-diyl))bis(2,5-dichlorobenzenesulfonamide)
KC7F2 is a small molecule HIF-1 pathway inhibitor that inhibits HIF-1α protein translation, but not transcription.
It inhibits hypoxia-induced expression of several HIF target genes, such as carbonic anhydrase IX, matrix metalloproteinase 2, enolase 1, and endothelin 1. KC7F2 is cytotoxic to a variety of cancer cell lines with an IC₅₀ value of 15-25 µM.
Formula:
C₁₆H₁₆Cl₄N₂O₄S₄ MW: 570.38 g/mol |
MDL Number:
MFCD22683809 CAS Number: 927822-86-4 UN: 3316 |
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