JH-II-127
Synonyms:
(4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone
JH-II-127 is a highly potent, selective, and cell-permeable LRRK2 inhibitor, with IC₅₀ of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T.
JH-II-127 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-03 μM in a variety of cell types and is capable of inhibiting Ser935 phosphorylation in mouse brain following oral delivery of doses as low as 30 mg/kg.
Formula:
C₁₉H₂₁ClN₆O₃ MW: 416.87 g/mol |
MDL Number:
MFCD28975160 CAS Number: 1700693-08-8 UN: 3316 |
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