U-104

Synonyms: 4-(3-(4-Fluorophenyl)ureido)benzenesulfonamide4-(3-(4-Fluorophenyl)ureido)benzenesulphonamide

9631-25 9631-5
75837-694EA 99.24 USD
75837-694 75837-696
U-104
U-104

U-104 is a ureido-sulfonamide inhibitor of transmembrane carbonic anhydrase IX (CAIX) (Ki = 45.1 nM) and XII (CAXII) (Ki = 4.5 nM).


It displays weaker affinity for the cytosolic isoforms, CAI and CAII (Kis = 5.08 and 9.64 µM, respectively). U-104 associates with CAIX/CAXII only under hypoxic conditions in vivo, reducing extracellular acidity and resulting in significant inhibition of tumor growth and metastasis in experimental models.

Formula: C₁₃H₁₂FN₃O₃S
MW: 309.32 g/mol
MDL Number: MFCD00159265
CAS Number: 178606-66-1
UN: 3316

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