U-104
Synonyms:
4-(3-(4-Fluorophenyl)ureido)benzenesulfonamide
, 4-(3-(4-Fluorophenyl)ureido)benzenesulphonamide
U-104 is a ureido-sulfonamide inhibitor of transmembrane carbonic anhydrase IX (CAIX) (Ki = 45.1 nM) and XII (CAXII) (Ki = 4.5 nM).
It displays weaker affinity for the cytosolic isoforms, CAI and CAII (Kis = 5.08 and 9.64 µM, respectively). U-104 associates with CAIX/CAXII only under hypoxic conditions in vivo, reducing extracellular acidity and resulting in significant inhibition of tumor growth and metastasis in experimental models.
Formula:
C₁₃H₁₂FN₃O₃S MW: 309.32 g/mol |
MDL Number:
MFCD00159265 CAS Number: 178606-66-1 UN: 3316 |
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