BMS-299897
9606-5
9606-25
75837-496EA
671.3
USD
75837-496
75837-494
BMS-299897
BMS-299897
BMS-299897 is a potent, brain-permeant γ-secretase inhibitor (IC₅₀ = 12 nM).
Inhibits Aβ40 and Aβ42 formation in vitro (IC₅₀ values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo.
Displays no Notch toxicity.
Formula:
C₂₄H₂₁ClF₃NO₄S MW: 511.94 g/mol |
MDL Number:
MFCD12963627 CAS Number: 290315-45-6 UN: 3316 |
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